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KMID : 1103720170760060375
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Journal of the Korean Society of Radiology
2017 Volume.76 No. 6 p.375 ~ p.385
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Clinicopathological and Imaging Features of Breast Cancer in Korean Women under 40 Years of Age
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Kim Jun-Woo
Jang Mi-Jung
Kim Sun-Mi
Yun Bo-La
Lee Jong-Yoon
Kim Eun-Kyu
Kang Eun-Young
Park So-Yeon
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Abstract
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Purpose: To evaluate the clinicopathological and imaging features of mammography, ultrasonography, and magnetic resonance imaging (MRI) for breast cancer in Korean women under 40 years of age according to molecular subtypes.
Materials and Methods: We included 183 breast cancers in 176 consecutive women under 40 years old who had been diagnosed with breast cancer between January 2012 and November 2014. The patients' clinical and pathologic records were available as electronic medical records. A retrospective review of the pre-operative imaging studies was performed with 177 mammographies, 183 ultrasonographies, and 178 MRIs.
Results: Eighty-six percent (158/183) of lesions were symptomatic, with masses (147/183) as the most common presentation. Eighty percent (22/25) of the asymptomatic lesions were diagnosed via screening ultrasonography. The luminal A subtype was the most common (n = 79, 43%), human epidermal growth factor receptor 2-enriched subtype showed indistinct margins on mammography (p = 0.006), the triple negative subtype depicted a posterior enhancement on ultrasonography (p < 0.001) and rim enhancement on MRI (p < 0.001).
Conclusion: Breast cancers in Korean women under 40 years of age are commonly presented with a palpable mass, and luminal A is the most common molecular subtype. In our study, the imaging and pathologic characteristics of breast cancer in younger women were similar to those previously reported for older patients.
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KEYWORD
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Breast Cancer, Mammography, Ultrasonography, Magnetic Resonance Imaging, Young Adult
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